Autism 5.7 X more likely if both parents had high chemical intolerance - Dec 2024

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Parents With High Chemical Intolerance 6 Times More Likely to Have Child With Autism - Dec 2024

Children's Health Defender

Probable MAST CELL connection
Reports on the following study

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Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children - March 2024

J. Xenobiot. 2024, 14(1), 350-367; https://doi.org/10.3390/jox14010022
by Raymond F. Palmer 1,*,David Kattari 2,Rodolfo Rincon 1 andClaudia S. Miller 1
1 Dept. of Family and Community Medicine, University of Texas Health Science Center at San Antonio, TX 78229, USA
2 Marilyn Brachman Hoffman Foundation, Fort Worth, TX 75202, USA
* Author to whom correspondence should be addressed.

Background: We sought to replicate our 2015 findings linking chemical intolerance in parents with the risk of their children developing autism and/or ADHD. Drawing upon our 2021 discovery of a strong association between chemical intolerance and mast cells, we propose an explanation for this link. Methods: In a population-based survey of U.S. adults, we used the internationally validated Quick Environmental Exposure and Sensitivity Inventory (QEESI) to assess symptom severity and chemical intolerance. Parents were asked how many of their biological children had been diagnosed with autism and/or ADHD.

Results: Parents with chemical intolerance scores in the top versus bottom tenth percentile had 5.7 times the risk of reporting a child with autism and 2.1 times for ADHD.

Conclusions: High chemical intolerance scores among parents of children with autism, coupled with our 2021 discovery of mast cell activation as a plausible biomechanism for chemical intolerance, suggest that

• (1) the QEESI can identify individuals at increased risk,
• (2) environmental counseling may reduce personal exposures and risk, and
• (3) the global rise in autism and ADHD may be due to fossil-fuel-derived and biogenic toxicants epigenetically “turning on” or “turning off” critical mast cell genes that can be transmitted transgenerationally.

It is important to note that this study was observational in nature; as such, further research is needed using controlled trials to confirm causality and explore the proposed mechanism.
 Download the PDF from VitaminDWiki

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VitaminDwiki - Vitamin D, mast cells, bones, and allergies - Aug 2022

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VitaminDWiki – Autism category contains:

Autism category has 165 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

• Most Autism Risk factors are associated with low vitamin D - March 2014
• Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
• Autistics have half of the response to Vitamin D – RCT Oct 2018
• Vitamin D fights autism - trying to figure out how and why – May 2022

Autism TREATED by Vitamin D

• Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
• Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
• Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015

Autism PREVENTED by vitamins before and during pregnancy

• Autism risk is reduced by Vitamin D – early pregnancy or chlldhood – Umbrella review – July 2024
• Vitamin D and autism - treat: 300 IU per kg per day, prevent: during pregnancy 5,000 IU – Feb 2017
• Autism reduced 24% for each 4 ng more Vitamin D while pregnant ( ADHD 12%) – Feb 2024
• Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
• Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
• Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
• Low Vitamin D decreases fertility and increases subsequent autism, ADHD, etc – Feb 2018
• Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
• Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016

Autism and Vitamin D Receptor (not enough Vit D gets to the cells)
This list is automatically updated

Autism - other risk factors

• Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
• Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
• 20 X more Parkinson's and 100X more Autism with GMO soy in China
  • Note >100X increase in Autism while having GMO soy in the US

6 Autism and Virus/Vaccines

Dr. Cannell on Autism and Vitamin D in VitaminDWiki

• Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
• Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
• Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
• Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
• Autism treated by Vitamin D: Dr. Cannell - video June 2013
  • includes his list of 27 reasons to associate Vitamin D with Autism in 2013

7 studies: Autism reduced by Omega-3

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Autism 4X more likely if already have autistic child - unless take Vitamin D - perhaps similar for chemical intolerance ==> Autism

Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016

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See also: Mast Cells and Autism on the web - 2022?

The Autism Community in Action
What are Mast Cell Disorders?
Symptoms of Mast Cell Activation
Mast Cells & The Blood Brain Barrier
Treatment for Mast Cell Activation
Removing triggers
Supplements
Medications
Calming the immune response
Diagnosing ATOPIC (allergic-like) Diseases
Dark circles under the eyes
Dermatographia
Treat and observe for improvement
Lab work
Practitioners that can diagnose and treat mast cell activation
Additional Resources