Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases
Biomedicines 2022, 10(8), 1877; https://doi.org/10.3390/biomedicines10081877
by Giuseppe Murdaca 1,*,†ORCID,Alessandro Allegra 2,*,†ORCID,Alessandro Tonacci 3ORCID,Caterina Musolino 2,Luisa Ricciardi 4 andSebastiano Gangemi 4 ITALY
The immune system is made up by an extremely composite group of cells, whose regulated and harmonious activity is fundamental to maintain health. The mast cells are an essential effector of inflammatory response which is characterized by a massive release of mediators accumulated in cytoplasmic secretory granules. However, beyond the effects on immune response, mast cells can modify bone metabolism and are capable of intervening in the genesis of pathologies such as osteoporosis and osteopenia. Vitamin D is recognized to induce changes in bone metabolism, but it is also able to influence immune response, suppressing mast cell activation and IgE synthesis from B cells and increasing the number of dendritic cells and IL-10-generating regulatory T cells. Vitamin D deficit has been reported to worsen sensitization and allergic manifestations in several different experimental models. However, in clinical situations, contradictory findings have been described concerning the correlation between allergy and vitamin D deficit. The aim of this review was to analyze the close relationships between mast cells and vitamin D, which contribute, through the activation of different molecular or cellular activation pathways, to the determination of bone pathologies and the onset of allergic diseases.
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Is there an association between mast cells and Vitamin D? Asked Perplexity AI Dec 2024
Yes, there is a significant association between mast cells and Vitamin D. This relationship plays a crucial role in immune function, inflammation regulation, and mast cell stability.
Vitamin D's Impact on Mast Cells
Mast Cell Stabilization
Vitamin D has been shown to contribute to mast cell stabilization 1 7
When vitamin D binds to receptors on mast cells, it inhibits mast cell activation and helps stabilize these cells 1
This stabilization effect can lead to a reduction in the release of histamine and other inflammatory mediators, potentially alleviating symptoms associated with mast cell disorders.Immune Regulation
Vitamin D influences the immune response by suppressing mast cell activation and modulating the production of various immune components 3 6
It can promote the production of anti-inflammatory cytokines, such as IL-10, while reducing the release of pro-inflammatory mediators 2 4
Mechanisms of Action
Vitamin D Receptor (VDR) Interaction
Mast cells express vitamin D receptors (VDRs) 3 4
When vitamin D binds to these receptors, it initiates various cellular processes that contribute to mast cell stability and function regulation 7
.Molecular Pathways
Vitamin D influences several molecular pathways within mast cells:
- It forms complexes with Lyn, inhibiting the binding of Lyn to FcεRI and MyD88 7
- This interaction decreases the phosphorylation of Syk and reduces levels of MAPK and NF-κB 7
- Vitamin D can also bind to the promoter of TNF-α, decreasing its expression in mast cells 7
Clinical Implications
Vitamin D Deficiency
Low levels of vitamin D may result in spontaneous mast cell activation 5 7
This suggests that maintaining adequate vitamin D levels is crucial for individuals with mast cell disorders or those prone to allergic reactions.Therapeutic Potential
The ability of vitamin D to stabilize mast cells and reduce inflammation presents potential therapeutic applications 2 6
Supplementation with vitamin D might be beneficial for individuals with mast cell activation syndrome, histamine intolerance, or other allergic conditions.
Research Findings
Studies have demonstrated that:
- Vitamin D can increase IL-10 production in mast cells, which has anti-inflammatory effects 4
- Mast cells can convert 25OHD3 to the active form of vitamin D (1α,25(OH)2D3), further contributing to their own regulation 6
- UVB irradiation, which increases vitamin D production in the skin, can lead to mast cell-mediated reduction of skin inflammation, dependent on mast cell VDR expression 4
In conclusion, the relationship between mast cells and vitamin D is complex and multifaceted, with vitamin D playing a crucial role in mast cell stability, immune regulation, and inflammatory response modulation. This association underscores the importance of maintaining adequate vitamin D levels, especially for individuals with mast cell-related disorders.
VitaminDWiki – Bone - Health category contains
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items in Bone - Health category
See also
- Overviews: Osteoporosis, Fractures, Rickets Dental Hair
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articles are in both Bone and Magnesium categories
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articles are in both Bone and Vitamin K2 categories
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| 18 |
articles are in both Bone and Sports categories
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articles are in both Bone and Meta-analysis categories
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articles are in both Fractures and Meta-analysis categories
- Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- VitaminDWiki pages with BONE MINERAL DENSITY or BMD in title 25 pages as of Feb 2023
- Hearing loss is associated with soft bones in ear
- Perhaps prevented and treated by Vitamin D
- See also Overview of Rickets and Vitamin D Overview Osteoporosis and vitamin D
VitaminDWiki - Skin category contains
| 122 |
items below see also Overview Skin and vitamin D Psoriasis Acne Atopic Dermatitis and Eczema Chronic Hives
Cancer - Skin category listing has | 121 |
items
Overview Dark Skin and Vitamin D
Overview Suntan, melanoma and vitamin D
Burns, ulcers, and wounds healed by Vitamin D - many studies
Vitiligo (spotty skin) and Vitamin D, UVB - many studies
Warts removed by vitamin D injection - many studies
Skin Aging and Vitamin D - many studies
Vitamin D benefits your skin in 7 ways
106+ VitaminDWiki pages with ALLERG in title
This list is automatically updated
Items found: 105
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Major reduction allergies and asthma if the child was born in a sunny season (in Paris in this case) – April 2024 |
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20 Apr, 2024 |
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Vitamin D, mast cells, bones, and allergies - Aug 2022 |
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01 Feb, 2024 |
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Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies |
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26 Jan, 2024 |
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Food allergies associated with low Vitamin D - many studies |
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02 Sep, 2023 |
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Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023 |
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21 Jul, 2023 |
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Overview Rare Allergic reaction to vitamin D |
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15 Jul, 2023 |
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People allergic to Lanolin should not be allergic to vegan Vitamin D |
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20 Mar, 2023 |
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Allergic rhinitis sublingual therapy was 22X more successful if good level of Vitamin D – Feb 2023 |
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15 Mar, 2023 |
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Allergic to multiple foods: 4 in 10 kids, 5 in 10 adults (note: Vitamin D helps) - Dec 2022 |
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06 Jan, 2023 |
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Do you have symptoms of COVID, Flu , RSV, Colds, Allergy - Oct 2022 |
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28 Oct, 2022 |
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Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022 |
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18 Oct, 2022 |
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Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022 |
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26 May, 2022 |
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Small vitamin D doses while pregnant do not decrease infant allergies – meta-analysis Feb 2022 |
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03 Feb, 2022 |
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Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021 |
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21 Aug, 2021 |
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Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 |
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04 Aug, 2021 |
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Reasons why some Respiratory Allergy studies find that Vitamin D does not help much – June 2020 |
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21 Jun, 2020 |
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Found again – 400 IU of Vitamin D rarely provides any benefit (infant allergy in this case) – RCT June 2020 |
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11 Jun, 2020 |
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Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020 |
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12 Jan, 2020 |
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Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019 |
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31 Dec, 2019 |
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Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019 |
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30 Aug, 2019 |
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Allergic reactions to Insect sting decreased by topical Vitamin D (frequent) |
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09 Aug, 2019 |
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6 year-old children were 5X less likely to have food allergies if supplementing with vitamin D – July 2019 |
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24 Jul, 2019 |
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Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019 |
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23 Jul, 2019 |
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Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 |
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17 Jul, 2019 |
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Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014 |
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14 Jul, 2019 |
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Children with allergies often depressed and anxious (low micro-nutrients, such as vitamin D, were not mentioned) – July 2019 |
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10 Jul, 2019 |
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6X as many people with allergic rhinitis were severely vitamin D deficient – Jan 2012 |
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30 Jun, 2019 |
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Peanut and Food allergies prevented by Vitamin D |
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26 Jun, 2019 |
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Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017 |
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24 Jun, 2019 |
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Prevalence and Severity of Food Allergies Among US Adults (vitamin D is not mentioned) – Jan 2019 |
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24 Jun, 2019 |
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Prenatal Omega-3 somewhat reduced child allergies (should also reduce Omega-6) – RCT June 2018 |
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17 Apr, 2019 |
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Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019 |
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24 Jan, 2019 |
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Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune... 145 slides- 2017 |
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30 Dec, 2018 |
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Allergy - Overview |
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18 Dec, 2018 |
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Childhood Food Allergies (UK 1 in 14) – huge recent increase (low vitamin D) - Dec 2018 |
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04 Dec, 2018 |
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Soy associated with food allergies in mice (perhaps Roundup) – Nov 2018 |
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21 Nov, 2018 |
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Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune, etc – slides May 2017 |
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02 Jul, 2018 |
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Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014 |
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01 Jul, 2018 |
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Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018 |
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02 Apr, 2018 |
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Food allergies are associated with Vitamin D thru genes, etc. – March 2018 |
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29 Mar, 2018 |
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Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018 |
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31 Jan, 2018 |
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Rare allergy to Vitamin D cured by progressive Desensitization - 2016 |
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04 Nov, 2017 |
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Milk – Vitamin D deficiency 2X more likely if lactose intolerant, milk allergy, or low fat milk – 2017 |
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03 Nov, 2017 |
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Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015 |
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07 Aug, 2017 |
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Increased cows milk allergy if Folic acid or Folate added to vitamin D during pregnancy – June 2016 |
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05 Apr, 2017 |
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Infant allergy to cow’s milk will go away if have high levels of vitamin D – Jan 2017 |
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19 Jan, 2017 |
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Woman with rare allergy to vitamin D was desensitized in a single day – Dec 2016 |
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21 Dec, 2016 |
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Childhood allergy, asthma and eczema associated with repeated low vitamin D tests – Oct 2016 |
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16 Dec, 2016 |
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Hay fever (allergic rhinitis) risk reduced 20 percent for each 100 IU of vitamin D during early pregnancy – Feb 2016 |
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23 Aug, 2016 |
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Allergies and asthma – overwhelming experimental evidence that vitamin D helps – more studies needed – Dec 2014 |
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03 Aug, 2016 |
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Does too much Vitamin D cause problems – possible for allergies, maybe for falls – Review June 2016 |
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26 Jun, 2016 |
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Food allergies and low vitamin D – thymus may be the connection – June 2016 |
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17 Jun, 2016 |
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More childhood allergies when vitamin D is less than 15 ng – Feb 2011 |
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17 Jun, 2016 |
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3X more allergy to peanuts if child born with low UV – Feb 2011 |
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17 Jun, 2016 |
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Still unsure of association between vitamin D and asthma and allergies – review April 2012 |
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17 Jun, 2016 |
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Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel – Dec 2011 |
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17 Jun, 2016 |
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Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014 |
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17 Jun, 2016 |
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Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015 |
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17 Jun, 2016 |
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Food allergies 6 times higher in South Australia - 2009 |
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28 May, 2016 |
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11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013 |
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17 Apr, 2016 |
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Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016 |
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17 Apr, 2016 |
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Increasing amount of omega-3 in mother’s milk resulted in fewer infant allergies – March 2016 |
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04 Apr, 2016 |
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New Zealand – new 50,000 IU vitamin D capsule has soy which can cause allergic reactions – March 2016 |
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09 Mar, 2016 |
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Photosensitivity (sun allergy) and vitamin D |
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26 Jan, 2016 |
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Allergic to the sun (Polymorphic light eruption) – you may need UVB or vitamin D |
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26 Jan, 2016 |
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Asthma associated with low vitamin D, independent of allergic status – Nov 2015 |
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25 Nov, 2015 |
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Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015 |
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02 Nov, 2015 |
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Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014 |
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22 Oct, 2015 |
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Severe allergy (Anaphylaxis) is increasing and is associated with low vitamin D – Sept 2015 |
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12 Sep, 2015 |
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Huge increase in food allergies in Australia may be due to low vitamin D |
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05 Sep, 2015 |
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Food allergy and low vitamin D – unsure – June 2013 |
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02 Sep, 2015 |
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Vitamin D, Vitamin A, or Vitamin E association with allergies and asthma – Feb 2012 |
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22 Aug, 2015 |
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Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015 |
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16 Aug, 2015 |
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High level of maternal vitamin D and infant food allergy – controversy |
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16 Aug, 2015 |
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Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 |
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01 Aug, 2015 |
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Allergic rhinitis associated with less vitamin D in men yet more in women – Jan 2014 |
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05 Jul, 2015 |
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Off topic: Large dose of Vitamin A increased allergic reaction in girls by 1.8X – RCT May 2015 |
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02 May, 2015 |
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Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015 |
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06 Jan, 2015 |
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Allergies and low vitamin D strongly associated with night shift bakers– Sept 2014 |
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26 Dec, 2014 |
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Allergy to House dust mite greatly reduced by adding just 600 IU of vitamin D – RCT Nov 2014 |
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14 Sep, 2014 |
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One issue of Inflammation and Allergy-Drug Targets has vitamin D items behind paywall– June 2013 |
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03 May, 2014 |
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30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012 |
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23 Apr, 2014 |
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Perhaps wool allergy is the cause of some Vitamin D allergy |
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15 Apr, 2014 |
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Being told you have allergies is associated with less than 10 ng vitamin D – Nov 2011 |
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29 Jan, 2014 |
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Vitamin D in Allergic and Immune Disorders - Nov 2013 |
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18 Nov, 2013 |
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Allergic rhinitis 56 percent more likely if low vitamin D – Nov 2013 |
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23 Oct, 2013 |
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Vitamin D supplements increased probability of allergic rhinitis by 66 percent - 2004 |
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23 Oct, 2013 |
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Is Vitamin D Supplementation Responsible for the Allergy Pandemic – May 2012 |
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27 Jun, 2012 |
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Food allergy 80 percent more likely if have certain genes and vitamin D deficient – Nov 2011 |
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15 Jun, 2012 |
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Vitamin D, Allergy, and genetics – June 2012 |
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15 Jun, 2012 |
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Vitamin D less than 15 ng associated with some allergies – Feb 2011 |
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11 Jun, 2012 |
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Crescendo of papers on Asthma, Allergy, and Vitamin D – Sept 2011 |
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11 Jun, 2012 |
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Allergic diseases in the elderly – Oct 2011 |
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10 Jan, 2012 |
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Vitamin D in asthma and allergy – editorial Dec 2011 |
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05 Dec, 2011 |
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Allergies and bone health may be connected by vitamin D – Sept 2011 |
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31 Aug, 2011 |
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Hypothesis - vitamin D supplements caused allergy pandemic – 2009 |
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04 Aug, 2011 |
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Are microbs – probiotics – vitamin D – allergy – asthma – obesity related – Mar 2011 |
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20 Jul, 2011 |
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Vitamin D and allergy to common mold - Aug 2010 |
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27 Mar, 2011 |
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2X more allergies if 11th womb week was in Spring – Vitamin D or pollen Oct 2010 |
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20 Oct, 2010 |
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Review of vitamin D asthma and allergic diseases – abstract lacks details July 2010 |
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20 Aug, 2010 |
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Mechanisms for hypothesis between sunshine and food allergy - July 2010 |
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07 Aug, 2010 |
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Vitamin D may be linked to food allergies by intestinal flora – July 2010 |
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20 Jul, 2010 |
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Speculation on elderly Food Allergies and Vitamin D – June 2010 |
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17 Jun, 2010 |
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Winter babies are more prone to food allergies |
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25 Apr, 2010 |
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Low vitamin D newborns getting cows milk formula more likely to get allergies – RCT Oct 2019 |
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