Poor Vitamin D receptor reduced vitamin D levels -meta-analysis Jan 2022

Note: Most studies find poor VDR reduces Calcitriol getting the mitocondria, this study finds it reduces Calcidiol to blood

---

Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis

Nutrients 2022,14,360. https://doi.org/10.3390/ nu14020360
Ricardo Usategui-Martín 1,2,% Daniel-Antonio De Luis-Román3,4A José María Fernández-Gómez Marta Ruiz-Mambrilla 7 and José-Luis Pérez-
IOBA, University of Valladolid, 47011 Valladolid, Spain
Cooperative Health Network for Research (RETICS), Oftared, National Institute of Health Carlos III, ISCIII, 47011 Madrid, Spain
Department of Endocrinology, Clinical University Hospital, 47002 Valladolid, Spain; dluisro at saludcastillayleon.es
Department of Medicine, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain
Instituto de Endocrinología y Nutrición (IENVA), University of Valladolid, 47002 Valladolid, Spain
Department of Cell Biology, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain; josefg at med.uva.es
Department of Surgery, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain; martamaria.ruiz at uva.es
Department of Internal Medicine, Río Hortega University Hospital, 47002 Valladolid, Spain

• Correspondence: ricardo.usategui at uva.es (R.U.-M.); joseluis.perez at uva.es (J.-L.P.-C.)

The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001).
In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation.

---

VitaminDWiki - The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019__

---

VDR can be activated

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators

---

VitaminDWiki - Resveratrol improves health (Vitamin D receptor, etc.) - many studies has:

• The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
• Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
• Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
• Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
  • Quercetin and Curcumin in the case of Resveratrol

18 articles in both of the categories Resveratrol and Vitamin D Receptor

---

VitaminDWiki - Vitamin D Receptor category has:

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

---

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

---

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR