Small doses for a short time rarely help (Omega-3, post surgery this time) – meta-analysis Nov 2023

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Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis

Nutrients 2023, 15(15), 3414; https://doi.org/10.3390/nu15153414
Ghaith Mohsen 1,*,Annika Stroemer 2ORCID,Andreas Mayr 2ORCID,Andrea Kunsorg 1,Christian Stoppe 3,4ORCID,Maria Wittmann 1ORCID and Markus Velten 1ORCID

Initial evidence indicates that preoperatively initiated administration of omega-3 fatty acids (FAs) attenuates the postoperative inflammatory reaction. The effects of immunonutrition containing omega-3 FAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the inflammatory response to abdominal surgery continues to be unclear, although improved outcomes have been reported. Therefore, we determined the effectiveness of preoperatively initiated omega-3 FAs administration on postoperative inflammation defined as CRP (C-Reactive Protein), IL-6 (Interleukin 6), and WBC (White Blood Count) and potential effects on postoperative length of hospital stay (LOS) due to an improved inflammatory response.

Methods: a literature search of Cochrane Library was conducted to identify all randomized controlled trials (RCTs) investigating the effects of preoperatively initiated omega-3 to standard care, placebo, or other immunonutrients excluding omega-3 FAs in patients undergoing abdominal surgery until the end of December 2022.

Results: a total of 296 articles were found during the initial search. Thirteen RCTs involving 950 patients were identified that met the search criteria. These were successively analyzed and included in this meta-analysis. There was no significant difference between the groups with respect to inflammatory markers IL-6: −0.55 [−1.22; 0.12] p = 0.10, CRP: −0.14 [−0.67; 0.40] p = 0.55, WBC: −0.58 [−3.05; 1.89] p = 0.42, or hospital stay −0.5 [−1.43; 0.41] p = 0.2.

Conclusion: although reduced inflammatory markers were observed, preoperative administration of omega-3 FAs immunonutrients had no significant effect on the postoperative inflammatory response in patients undergoing abdominal surgeries. Yet, results obtained from this study are inconclusive, likely attributed to the limited number of trials and patients included. Further studies are required to obtain a better educated verdict.

 Download the PDF from VitaminDWiki

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The mistake of trying to find a benefit from small doses for a short time is often a problem for Omega-3, Vitamin D, Magnesium, etc.

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Probably need 1 gram/day pf Omega-3 for months, with fatty meal, AND Omega-6 intake MUST be reduced

• Omega-6 blocks Omega-3 etc. -many studies
• Emulsified form of Omega-3 is 3X more bioavailable in low fat meal – Dec 2019

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VitaminDWiki - 23 Omega-3 meta-analyses

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VitaminDWiki - Overview: Omega-3 many benefits include helping vitamin D

(407) items in category Omega-3 and Vitamin D

• Omega-3 reduces risk of COVID-19 - many studies
• Cardiovascular problems reduced by Omega-3 - many studies
• Omega-3 helps muscles - many studies
• Omega 3 increases vitamin D in the blood – many studies
• Omega-3 index - many studies
• Omega-6 blocks Omega-3 etc. -many studies
• Omega-6 increase may have increased the risk of many diseases - Jan 2022
• Preterm birth decreased by Omega-3, etc. - many studies
• Omega-3 reduces many psychiatric disorders – 2 reviews 2016
• ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
• Schizophrenia relapses reduced 3X by Omega-3 – RCT Mar 2015
• Typical pregnancy is now 39 weeks – Omega-3 and Vitamin D might restore it to full 40 weeks
• Omega-3 supplementation during pregnancy reduce early preterm births (save 1500 USD per child) – Aug 2016
• Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017
• Omega-3 conference and 12 publications – Nov 2014
• Vitamin D Cofactors in a nutshell by VitaminDWiki
• For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
• Overweight women on caloric restriction diet got 3X benefits from 8 weeks of Omega-3 – RCT Dec 2015
• 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
• Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
• Omega-7 - in addition to Omega-3
• Consuming more monounsaturated fat increased vitamin D – Aug 2011 has the following
  WikiPedia Good (more vitamin D into bloodstream)= much more BLUE than Green

Almonds and macadamia nuts are examples of good foods to take with vitamin D

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VitaminDWiki - Omega-3 helps many health problems

407 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (52 studies), Pregnancy (44 studies), Infant (34 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details

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60+ VitaminDWiki pages have TRANSCRIPT in the title

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