The Role of Magnesium in the Pathogenesis of Metabolic Disorders
Nutrients 2022, 14(9), 1714; https://doi.org/10.3390/nu14091714
by Marta Pelczyńska *ORCID,Małgorzata MoszakORCID and Paweł BogdańskiORCID
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznań University of Medical Sciences, 84 Szamarzewskiego Street, 60-569 Poznań, Poland
Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It is involved in many fundamental processes, and Mg deficiency is often correlated with negative health outcomes. On the one hand, most western civilizations consume less than the recommended daily allowance of Mg. On the other hand, a growing body of evidence has indicated that chronic hypomagnesemia may be implicated in the pathogenesis of various metabolic disorders such as
- overweight and obesity,
- insulin resistance (IR) and type 2 diabetes mellitus (T2DM),
- hypertension (HTN),
- changes in lipid metabolism, and
- low-grade inflammation.
High Mg intake with diet and/or supplementation seems to prevent chronic metabolic complications. The protective action of Mg may include limiting the adipose tissue accumulation, improving glucose and insulin metabolism, enhancing endothelium-dependent vasodilation, normalizing lipid profile, and attenuating inflammatory processes. Thus, it currently seems that Mg plays an important role in developing metabolic disorders associated with obesity, although more randomized controlled trials (RCTs) evaluating Mg supplementation strategies are needed. This work represents a review and synthesis of recent data on the role of Mg in the pathogenesis of metabolic disorders.
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Magnesium: Obesity + Hypertension
Meta-analyses in study
VitaminDWiki - Magnesium and Obesity
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- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- More Magnesium needed by obese (Mg Sulfate, women in this case) – RCT Dec 2021
- PTH failed to decrease with Vitamin D if overweight and had low Magnesium – Aug 2019
- Magnesium may help with calorie restriction, ALS, and R-loops in DNA - LEF Oct 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Obesity epidemic: a perfect storm of deficiency of vitamin D, Magnesium, Iodine, etc – May 2012
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VitaminDWiki - Magnesium and Hypertension
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- Magnesium raised Vitamin D, lowered blood pressure and Ca to Mg ratio – RCT Sept 2024
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- Magnesium reduces hypertension - FDA allows claim - Jan 2022
- Hypertension reduced by Magnesium plus 3,000 IU of vitamin D for 12 weeks – RCT July 2022
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Hypertension treatment needs at least 600 mg of Magnesium (49 trials) – Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Reduce blood pressure by 9 mm with triple hypertensive drug or 19 mm with Magnesium – April 2018
- Hypertension nonconventional therapies: Magnesium, melatonin, Vitamin C, etc. – Jan 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
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VitaminDWiki - Magnesium and Diabetes
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- Treating pre-diabetes with Magnesium Chloride should be cost effective – June 2022
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- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
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- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
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- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
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Magensium and Inflammation
Chart Mg and Low-grade Inflammation
Meta-analyses in study
VitaminDWiki Magnesium and Inflammation
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VitaminDWiki - Magnesium and Vitamin D contains
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Mg and Vitamin D
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Magnesium associations in VitaminDWiki (More than 4)
Summary of Associations
Associated category | Associations |
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Results
16 pages in both categories: Vitamin D and Magnesium + Bone - Health
5 pages in both categories: Vitamin D and Magnesium + Falls and Fractures
28 pages in both categories: Vitamin D and Magnesium + Vitamin D and Calcium
26 pages in both categories: Vitamin D and Magnesium + Virus
14 pages in both categories: Vitamin D and Magnesium + Vitamin B12
34 pages in both categories: Vitamin D and Magnesium + Top news
28 pages in both categories: Vitamin D and Magnesium + Vitamin D and Vitamin K
38 pages in both categories: Vitamin D and Magnesium + Vitamin D and Omega-3
17 pages in both categories: Vitamin D and Magnesium + Cardiovascular
7 pages in both categories: Vitamin D and Magnesium + Interactions with Vitamin D
11 pages in both categories: Vitamin D and Magnesium + Headache
24 pages in both categories: Vitamin D and Magnesium + Zinc
9 pages in both categories: Vitamin D and Magnesium + Mortality and D
8 pages in both categories: Vitamin D and Magnesium + Cognitive
14 pages in both categories: Vitamin D and Magnesium + Depression
5 pages in both categories: Vitamin D and Magnesium + Breathing
10 pages in both categories: Vitamin D and Magnesium + Books, videos on Vitamin D
14 pages in both categories: Vitamin D and Magnesium + Vitamin D and Iron
7 pages in both categories: Vitamin D and Magnesium + Pain - chronic
5 pages in both categories: Vitamin D and Magnesium + Cancer - Breast
12 pages in both categories: Vitamin D and Magnesium + Supplement
9 pages in both categories: Vitamin D and Magnesium + Vitamin D and Boron
7 pages in both categories: Vitamin D and Magnesium + Iodine
29 pages in both categories: Vitamin D and Magnesium + Diabetes
9 pages in both categories: Vitamin D and Magnesium + Intervention
11 pages in both categories: Vitamin D and Magnesium + Vitamin C
7 pages in both categories: Vitamin D and Magnesium + Vitamin D and Vitamin A
6 pages in both categories: Vitamin D and Magnesium + Resveratrol
9 pages in both categories: Vitamin D and Magnesium + Metabolic Syndrome
5 pages in both categories: Vitamin D and Magnesium + Osteoporosis
11 pages in both categories: Vitamin D and Magnesium + Pregnancy
8 pages in both categories: Vitamin D and Magnesium + Seniors
5 pages in both categories: Vitamin D and Magnesium + Cancer
8 pages in both categories: Vitamin D and Magnesium + Deficiency of Vitamin D
11 pages in both categories: Vitamin D and Magnesium + Obesity
13 pages in both categories: Vitamin D and Magnesium + Hypertension
5 pages in both categories: Vitamin D and Magnesium + Trauma and surgery
6 pages in both categories: Vitamin D and Magnesium + Kidney
5 pages in both categories: Vitamin D and Magnesium + Women
5 pages in both categories: Vitamin D and Magnesium + Associations
Page | Hits | Categories | Major change |
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Magnesium Depletion Score predicts increased risk of various health problems | 672 | Kidney, Diabetes, Osteoporosis, Vitamin D and Magnesium, Kidney Stones, Hypertension, Sleep, Associations | 05 Jun, 2024 |
Overview Magnesium and vitamin D | 389898 | Obesity, Vitamin D and Magnesium, Overviews, Associations, AI | 12 Jul, 2023 |
The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022 | 1950 | Diabetes, Obesity, Vitamin D and Magnesium, Metabolic Syndrome, Top news, Hypertension, Cholesterol, Inflammation, Associations | 23 Apr, 2022 |
Headache | 82343 | Vitamin D and Magnesium, Headache, Category , Associations | 20 Apr, 2022 |
Magnesium fights diabetes (yet again)– meta-analysis Nov 2021 | 2074 | Diabetes, Vitamin D and Magnesium, Meta-analysis of Vitamin D, Associations | 20 Apr, 2022 |
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